GCAT

GCAT cohort belongs to GCAT | Genomes for life project, a longitudinal study with 19,000 volunteers conducted in Catalonia (Spain), a Mediterranean region of South Europe. Individuals have already been recruited (2014-2017) and are currently under follow-up (2018).

GCAT is a population-based multi-purpose cohort aimed to identify genomic, epigenomic, environmental and lifestyle factors as well as their interactions implicated in the development multi-factorial chronic diseases with complex inheritance (e.g. cancer, cardiovascular, respiratory, autoimmune, neurological or metabolic diseases).

GCAT participants are representative of the adult Catalan general population in terms of geography, age and gender distributions according to the official census. GCAT inclusion criteria include individuals ? 40 years of age and <67, living in Catalonia and with Spanish National Health Service (NHS) universal coverage.

GCAT Omic Data (i.e., genome, metabolome) is currently available from 6.200 participants (randomly selected from the GCAT cohort with a 1:1 gender proportion); 5.600 SNP genomic profiles have been characterized using Illumina Infinium SNP-bead array technology plus Imputation (i.e. 9,000K variants), Whole Genome Sequencing of 808 participants (coverage of 30X), and 200 participants (targeted-subexome sequencing approach for hereditary cancer genes).

GCAT Clinical Diagnoses and health variables from whole cohort are obtained from self-reported interviews and from Electronic Medical Record (EMR) linking to the Catalan Health Institute (CHI) / Spanish National Health Service (NHS).

Genomes for Life provide an exceptional opportunity to provide clinical interpretation of genomes, by integrating clinical, life-style and omic data in a large dynamic cohort.

Complete cohort profile is described in Obon-Santacana M, Vilardell M, Carreras A, et al. GCAT|Genomes for life: a prospective cohort study of the genomes of Catalonia. BMJ Open2018; 0:e018324. doi:10.1136/bmjopen-2017-018324

The variables of the study have been classified in areas of information and subareas, and summarized, and are available in the Datasets section below. The GCAT Questionnaire dataset has all the raw variables of the questionnaire, as they were asked; and the GCAT curated has been curated to be more meaningful.

Overview

Acronym

GCAT

Website

GCAT website

Investigator
Study Start Year

2014

Design

Study Design
  • cohort study
General Information on Follow Up (profile and frequency)

The active follow-up, death registry linkage, national health records will start in April 2017.

Recruitment Target
  • individuals
Target Number of Participants

22,000

Target Number of Participants with Biological Samples

22,000

Supplementary Information

15.604 participants have been recruited as of April 2017. The GCAT study collected the following biospecimen at baseline: Blood: 15.604 participants Plasma: 15.604 participants Serum: 15.604 participants DNA: 15.604 participants

Access

Access to external researchers or third parties provided or foreseen for:

Data (questionnaire-derived, measured...)

Biological Samples

Timeline

Each colour in the timeline graph below represents a separate Study Population, while each segment in the graph represents a separate Data Collection Event. Clicking on a segment gives more detailed information on a Data Collection Event.

Population

Cohort study

Sources of Recruitment

General Population volunteer

Selection Criteria

Age Minimum 40, Maximum 65
Country Spain
Territory Catalonia
Other To be resident of Catalonia, owner of Individual Health Card (TSI) and to have capacity to understand at least one of the official languages (Spanish or Catalan)

Sample Size

Number of Participants

22,000

Number of Participants with Biological Samples

22,000

Data Collection Events

NameDescriptionStartEnd
Initial recruitment2014 (June)2017 (June)
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Variable Classification

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